INDUCING UBIQUITINATION AND DEGRADATION OF TRXR1 PROTEIN BY LW-216 PROMOTES APOPTOSIS IN NON-SMALL CELL LUNG CANCER VIA TRIGGERING ROS PRODUCTION

Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production

Thioredoxin reductases are frequently overexpressed in various solid tumors as a protective mechanism against heightened oxidative stress.Inhibitors of this system, such as Auranofin, are effective in eradicating cancer cells.However, the clinical significance of thioredoxin reductase 1 (TrxR1) in lung cancer, as well as the potential for its antag

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Awake thoracic epidural anaesthesia for laparotomy: A safer alternative to general anaesthesia in asthmatic patients

Asthma is a common obstructive lung disease with a hallmark of airway inflammation Gift Card and hyper-reactivity in response to a variety of stimuli.The morbidity and mortality in asthma is directly related to reversible airway obstruction and bronchospasm in response to specific triggers.The goal of the anaesthetist is to avoid eliciting triggeri

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The importance of seismic protection of strategic objectives, in the area of influence of useful rock quarries, in which blasting works are carried out

In this scientific article was studied the main methods for assessing the seismic effect generated during the blasting operations with explosives, from quarries on essential infrastructure Hat elements, in the analyzed situation - railway tunnel and supporting pillars of the railway superstructure in the adjacent area of the quarry, regarding the m

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Comparison of Spermophilus dauricus gastrointestinal phenotypic flexibility between hibernating and non-hibernating seasons

Traits of the gastrointestinal (GI) tract are phenotypically flexible and seem to reflect the ecological features of animals.The Daurian ground squirrel (Spermophilus dauricus) is a typical fat-storing, hibernating animal.However, information on seasonal GI plasticity in this species is limited.The aim of the present study was to characterize the m

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